June 29, 2023
Understanding NAD+: Ultimate Guide


Every day, we are bombarded with countless claims about miracle supplements and quick fixes to our health concerns. However, amidst the noise, there is one research-backed nutrient that has garnered significant recent attention: nicotinamide adenine dinucleotide or NAD+.  NAD+ is a powerful molecule found in every cell in our bodies, and understanding its benefits – and how to optimize your NAD+ levels – can help you live your best life!

In this comprehensive guide, we'll dive deep into understanding NAD+ and its vast array of benefits, ranging from elevated energy, improved mitochondrial health, and decreased inflammation, to increased longevity, exercise performance, and recovery. This molecule does it all! Additionally, we'll examine the various methods of NAD+ supplementation, such as NAD+ intravenous (IV) infusion, NAD+ therapy, NAD IV therapy, and the most user-friendly delivery approach – the NAD+ patch. 

What is NAD+?

NAD+ might not be a household name, but this essential molecule plays a vital role in maintaining your overall health and wellbeing. NAD+ is a coenzyme found in every living cell and is involved in many biological processes, including energy production, DNA repair, and cell signaling. 

The Many Roles of NAD+

NAD+ is involved in numerous cellular processes, each highlighting its significance in maintaining optimal health. Some of the key roles of NAD+ include:

  1. Energy production: As mentioned earlier, NAD+ is essential for cellular respiration, the process by which our cells convert nutrients into energy. It is a critical component of the electron transport chain, a series of protein complexes in the mitochondria responsible for generating ATP.
  2. DNA repair: NAD+ is required for the function of proteins called PARPs (poly ADP-ribose polymerases), which are involved in detecting and repairing damaged DNA. By facilitating DNA repair, NAD+ helps maintain the integrity of our genetic material and protect our cells from mutations that could lead to diseases like cancer.
  3. Cell signaling: NAD+ also acts as a substrate for sirtuins, a family of proteins that regulate various cellular processes, including gene expression, metabolism, and aging. Sirtuins play a crucial role in maintaining cellular health and have been linked to longevity and age-related diseases.
  4. Immune function: NAD+ has been shown to play a role in regulating immune responses and inflammation. By modulating the activity of certain enzymes, NAD+ can help control the production of inflammatory molecules, thereby contributing to a balanced immune system.

The Decline of NAD+ Levels and Its Impact on Health

As we age, our NAD+ levels naturally decline. This decline has been linked to a host of health issues, including cognitive decline, metabolic disorders, and decreased immune function. 

Fortunately, there are ways we can boost our NAD+ levels naturally, such as through regular exercise, a balanced diet, and sufficient sleep, as well as through direct supplementation – which will be further examined below. But first, let's explore the host of benefits that come with optimizing your NAD+ levels. 

Increased Energy and Metabolism

Do you constantly feel drained, fatigued, or suffer from a lack of energy? If so, NAD+ might be the game-changer you've been searching for!  When NAD+ levels are optimal, our cells can produce energy more efficiently, keeping us energized and alert throughout the day. 

One of the primary ways in which NAD+ supplementation may increase energy is by supporting mitochondrial health and function. Mitochondria, often referred to as the “powerhouses” of our cells, are the primary sites for energy production. They are responsible for generating ATP (adenosine triphosphate), which serves as the energy currency for all cellular activities. With more ATP available, your body can efficiently fuel your daily activities, leaving you feeling energized and ready to conquer your day! 

Another way in which NAD+ supplementation may increase energy is by supporting cellular metabolism. An efficient and well-functioning cellular metabolism is essential for maintaining optimal health. When our metabolic processes are running smoothly, our bodies can effectively break down nutrients, generate energy, and eliminate waste products. This, in turn, supports various vital bodily functions, such as maintaining a healthy weight, supporting organ function, and promoting overall well-being. By boosting NAD+ levels and revving up our metabolism, we are essentially “fine-tuning” our bodies to function at their best.

Better DNA Repair and Reduced Inflammation 

Picture this: every day, our DNA experiences countless assaults from various sources, such as environmental factors, lifestyle choices, and even our own metabolism. Over time, these attacks result in DNA damage, which has been linked to an array of diseases and, of course, aging itself. In fact, studies have shown that DNA damage contributes to age-related diseases such as cancer, neurodegenerative disorders, and cardiovascular disease, among others.

But not all heroes wear capes. Enter NAD+, the superhero molecule that swoops in to save the day. Researchers have found that NAD+ supplementation can significantly enhance DNA repair and synthesis, as well as liver regeneration. In other words, NAD+ is like the ultimate bodyguard for our genetic material!

But that's not all. NAD+ also has a hand in angiogenesis, the process by which new blood vessels form from pre-existing ones. This is a crucial mechanism in the body, as it promotes the delivery of oxygen and nutrients to various tissues and organs. By boosting angiogenesis, NAD+ not only ensures that our cells receive the vital support they need, but also contributes to overall health and well-being.

Elevating NAD+ levels has also displayed promising results in the realm of inflammation, with studies indicating a decrease in inflammation markers like TNFa and IL-6. By reducing these markers, NAD+ supplementation has been linked to alleviating symptoms associated with inflammatory autoimmune conditions. This remarkable finding underscores the potential benefits of NAD+ in promoting overall health and well-being by mitigating inflammation, a key factor in many chronic illnesses. By embracing the remarkable benefits of NAD+ supplementation, we're paving the way for a brighter, healthier future. Now, that's something to get excited about!

Anti-Aging and Improved Longevity

One of the most exciting potential benefits of NAD+ is its anti-aging effects. NAD+ levels decline with age, and this decline in NAD+ levels is causally linked to numerous aging-associated diseases, including cognitive decline, cancer, metabolic disease, sarcopenia and frailty. But fear not, many of these are-related diseases can be slowed down and even reversed by restoring your NAD+ levels!

Picture NAD+ as the “master key” that unlocks the potential of sirtuins, a family of proteins known for their role in aging and various cellular processes. Sirtuins, often referred to as the “longevity genes,” are involved in DNA repair, metabolism, and cellular stress resistance, among other functions. The presence of NAD+ is crucial for sirtuins to perform these tasks, as it serves as a cofactor that enables their deacetylase activity. By boosting NAD+ levels, we can directly influence sirtuins’ actions and, in turn, potentially delay the onset of age-related diseases. 

Another exciting aspect of NAD+ and its role in longevity is its ability to influence cellular senescence – the process by which cells lose their ability to divide and function correctly. Senescent cells accumulate in our bodies as we age, and they contribute to inflammation, tissue dysfunction, and the development of age-related diseases. By restoring NAD+ levels, we can help to reduce the number of senescent cells and promote a healthier, more youthful cellular environment. This is great news for anyone who wants to age gracefully and stay healthy and vibrant well into their golden years.

So, what does this all mean for us in the grand scheme of things? Well, by supplementing with NAD+, we are essentially giving our bodies a leg up in the ongoing battle against DNA damage, inflammation, disease, and aging. This dynamic molecule provides us with a powerful tool to help maintain our health, vitality, and youthfulness for as long as possible. And who wouldn't want that?

Enhancing Exercise Performance and Recovery 

Imagine being able to increase your endurance, improve your workout capacity, and enhance your muscle recovery – all with the help of a single molecule. Sounds like a dream come true, right? Well, it's not just wishful thinking.

In a fascinating study published in the journal Cell Metabolism, researchers discovered that boosting NAD+ levels in mice led to some remarkable results. When NAD+ levels were increased, the mice experienced a noticeable improvement in endurance and capacity, allowing them to perform better in various physical tasks. This improvement can be attributed to enhanced mitochondrial function, leading to more efficient energy production and reduced fatigue. This finding could have significant implications for athletes and fitness enthusiasts alike.

Moreover, this study revealed the impact of NAD+ on muscle regeneration. When NAD+ levels were increased in the mice, there was an increase in stem cell activity and the regeneration of skeletal muscle tissue. This suggests that by boosting NAD+ levels, we can potentially tap into our body's natural ability to repair and rebuild damaged muscle tissue more effectively. The possibilities for speeding up recovery after an intense workout or even addressing muscle-wasting conditions are certainly intriguing. 

The researchers also found that increased NAD+ levels promoted stem cell activity. This is an important finding because stem cells play a vital role in our body's ability to repair and regenerate tissues, including muscle. This is particularly important as we age, as our muscles naturally lose mass and strength over time. By harnessing the power of NAD+, we can counteract this age-related decline and maintain a strong, healthy musculature well into our later years. Who wouldn't want to stay fit and active for as long as possible?

A Better Working Brain 

Is it possible to retain mental sharpness as we age? Recent studies have shown that NAD+ holds remarkable potential for supporting brain health and preventing neurodegenerative diseases such as Alzheimer's and Parkinson’s.

Alzheimer's and Parkinson's are two neurodegenerative diseases characterized by the progressive loss of brain cells and cognitive decline. Research has indicated that NAD+ can counteract the molecular processes that contribute to the development of these diseases. This suggests that increasing NAD+ levels could offer hope for those looking to delay or prevent the onset of these devastating conditions.

Our brains possess an astounding ability to adapt, continually reorganizing neural pathways through a process called neuroplasticity. This incredible characteristic is vital for learning and memory formation. Research has revealed that NAD+ plays an essential role in promoting neuroplasticity, ensuring our brains stay agile and receptive to new information. By boosting NAD+ levels, we could potentially uphold cognitive flexibility, allowing us to adapt and thrive in the face of new situations and challenges throughout our lives.

Therefore, by understanding the potential of NAD+ pathways, we can pave the way for innovative NAD+ therapies and strategies to preserve our cognitive abilities as we age. This exciting research gives us hope for a future where we can maintain our mental agility and enjoy a high quality of life well into old age.  

Improved Skin Health and Appearance

NAD+ has also been found to have a positive effect on skin health and appearance. As we age, our skin naturally loses its elasticity and firmness, leading to wrinkles, fine lines, and sagging. One of the factors contributing to the aging process in our skin is the decline of NAD+ levels in our bodies. However, there is good news! Research has demonstrated that by increasing NAD+ levels, we can help counteract these age-related changes in our skin. This is achieved through the promotion of collagen production, the reduction of inflammation, and support for the skin’s natural repair processes. The outcome? A smoother, more youthful appearance for your skin! 

Methods of NAD+ Supplementation

Now that you're aware of the incredible benefits that come with enhancing your NAD+ levels, you might be wondering, what's the best way to incorporate this powerful molecule into your routine? There are several methods of NAD+ supplementation that have been developed to increase NAD+ levels in the body. Let's dive in! 

NAD+ IV Infusion

One method of NAD+ supplementation is through intravenous (IV) infusion, also known as  NAD+ IV therapy. This involves injecting a solution containing NAD+ directly into the bloodstream, allowing for rapid absorption and utilization by cells.  NAD+ IV therapy is typically performed in a clinical setting and can take several hours to complete.  Unfortunately, NAD+ IV therapy can sometimes cause nausea due to the rapid introduction of the coenzyme into the bloodstream. As the body adjusts to the sudden increase in NAD+ levels, it may trigger a mild stress response, resulting in feelings of nausea. Additionally, the infusion process itself might contribute to the uneasiness, as some people are more sensitive to the sensation of having fluids introduced intravenously or have a fear of needles. Lastly, due to it being administered in a clinical setting by a professional, NAD+ IV therapy is notorious for its hefty price tag. 

NAD+ Patches

NAD+ patches are another method of supplementation that have gained popularity in recent years. NAD+ patches offer a more convenient and comfortable alternative to NAD+ IV therapy. They are non-invasive and eliminate the need for needles, making them a preferable option for those who are uncomfortable with or fearful of intravenous procedures. Additionally, NAD+ patches provide a steady, controlled release of the coenzyme, which allows for a more gradual absorption into the bloodstream. This slower release can help minimize potential side effects, such as nausea, that may occur with the rapid introduction of NAD+ during NAD+ IV therapy. Furthermore, patches can be easily applied and removed, giving users the flexibility to administer the treatment in the comfort of their own homes or on the go. Given their flexibility and ease of administration, NAD+ patches are also less cost prohibitive. 

Oral Supplements

Another method of NAD+ supplementation is through oral supplements. However, these supplements are not NAD+, but instead, contain precursors to NAD+, such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), which has been shown to convert into NAD+ by the body.  Oral supplements are widely available and can be purchased over-the-counter or online. They are typically taken daily and may take several weeks to months to produce noticeable effects.


NAD+ is a crucial coenzyme that participates in a multitude of biological processes, such as energy metabolism. As we age, our NAD+ levels naturally decline, resulting in reduced energy levels and heightened susceptibility to age-related diseases. 

Although additional research is necessary to uncover the full scope of its impact on human health, NAD+ supplementation has already demonstrated a vast array of potential benefits. These benefits span from enhanced mitochondrial health and metabolic flexibility to better exercise performance and recovery, as well as a range of impressive anti-aging effects. With such promising results, NAD+ therapy, like NAD+ patches and NAD+ IV infusion, truly has the potential to revolutionize how we approach increased energy, improved mitochondrial health, and overall longevity.